CHC

Preneoplastic lesions in the liver: Molecular insights and relevance for clinical practice

CHC, Cholangiocarcinome / By

Desjonqueres E, Campani C, Marra F, Zucman-Rossi J, Nault JC.Liver Int. 2022 Jan 4. doi: 10.1111/liv.15152.  Abstract Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are the most frequent primary liver cancers, accounting for approximately 80% and 15%, respectively. HCC carcinogenesis occurs mostly in cirrhosis and is a complex multi-step process, from precancerous lesions (low-grade and high-grade dysplastic …

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Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study

CHC / By

Eric Trépo, Stefano Caruso, Jie Yang, Sandrine Imbeaud, Gabrielle Couchy, Quentin Bayard, Eric Letouzé, Nathalie Ganne-Carrié, Christophe Moreno, Abderrahim Oussalah, Cyrille Féray, Jean Frédéric Blanc, Bruno Clément, Patrick Hillon, Jérôme Boursier, Valérie Paradis, Julien Calderaro, Viviane Gnemmi, Jean-Charles Nault, Jean-Louis Guéant, Jacques Devière, Isabelle Archambeaud, Carole Vitellius, Bruno Turlin, Jean-Pierre Bronowicki, Thierry Gustot, Angela Sutton, GENTHEP Consortium; Marianne Ziol, Pierre Nahon, Jessica Zucman-Rossi Lancet Oncology, Décembre 2021 Background: Hepatocellular carcinoma is a frequent consequence of alcohol-related liver disease, with variable incidence among heavy drinkers. We did …

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Impact of cirrhosis aetiology on incidence and prognosis of hepatocellular carcinoma diagnosed during surveillance

CHC / By

Nathalie Ganne-Carrié, Pierre Nahon, Cendrine Chaffaut, Gisèle N’Kontchou, Richard Layese, Etienne Audureau, Sylvie ChevretJ Hep reports octobre 2021 Background & aims: In this study we aimed to analyse the impact of the aetiology of cirrhosis on the incidence, characteristics and prognosis of hepatocellular carcinoma (HCC) diagnosed during a surveillance program. Methods: Individual data from a randomized trial …

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Non-invasive diagnosis and follow-up of benign liver tumours.

CHC / By

Nault JC, Blanc JF, Moga L, Calderaro J, Dao T, Guiu B, Hocquelet A, Paradis V, Salamé E, de Lédinghen V, Bourlière M, Bureau C, Ganne-Carrié N. Clin Res Hepatol Gastroenterol. 2021 Abstract Hepatocellular benign liver tumours are mainly developed on normal liver and include hepatic hemangioma, focal nodular hyperplasia and hepatocellular adenoma from the …

Non-invasive diagnosis and follow-up of benign liver tumours. Read More »