CHC

Louvet A, Trabut JB, Moreno C, Moirand R, Aubin HJ, Ntandja Wandji LC, Nourredine M, Ningarhari M, Ganne-Carrié N, Pageaux GP, Bailly F, Boursier J, Daeppen JB, Luquiens A, Nguyen-Khac E, Anty R, Orban T, Donnadieu-Rigole H, Mallat A, Bureau C, Pariente EA, Paupard T, Benyamina A, Perney P, Mathurin P, Rolland B; for the Groupe collaboratif …

Management of alcohol-related liver disease: the French Association for the Study of the Liver and the French Alcohol Society clinical guidelines Read More »

Calès P, Ravaioli F, Berger A, Farcau O, Festi D, Stefanescu H, Vitellius C, Nahon P, Bureau C, Ganne-Carriè N, Berzigotti A, de Ledinghen V, Petta S.Clin Res Hepatol Gastroenterol. 2022 Apr 22:101925. doi: 10.1016/j.clinre.2022.101925. Abstract Background and aims: We aimed to improve non-invasive screening of varices needing treatment (VNT) and compare different screening strategies. Methods: 2,290 patients …

Comparison of screening strategies with two new tests to score and diagnose varices needing treatment Read More »

Seehofer D, Petrowsky H, Schneeberger S, Vibert E, Ricke J, Sapisochin G, Nault JC, Berg T.Transpl Int. 2022 Apr 21;35:10333. doi: 10.3389/ti.2022.10333 Abstract Background and Aims: Morphometric features such as the Milan criteria serve as standard criteria for liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). Since it has been recognized that these criteria are too …

Patient Selection for Downstaging of Hepatocellular Carcinoma Prior to Liver Transplantation-Adjusting the Odds? Read More »

Hobeika C, Guyard C, Sartoris R, Maino C, Rautou PE, Dokmak S, Bouattour M, Durand F, Weiss E, Vilgrain V, Beaufrère A, Sepulveda A, Farges O, Paradis V, Luciani A, Lim C, Sommacale D, Scatton O, Laurent A, Nault JC, Soubrane O, Ronot M, Cauchy F.Br J Surg. 2022 Apr 19;109(5):455-463. doi: 10.1093/bjs/znac017. Abstract Background: Posthepatectomy liver …

Performance of non-invasive biomarkers compared with invasive methods for risk prediction of posthepatectomy liver failure in hepatocellular carcinoma Read More »

Lewin M, Laurent-Bellue A, Desterke C, Radu A, Feghali JA, Farah J, Agostini H, Nault JC, Vibert E, Guettier C. Abstract Purpose: Evaluation of perfusion CT and dual-energy CT (DECT) quantitative parameters for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC) prior to surgery. Methods: This prospective single-center study included fifty-six patients (44 men; median age 67; range …

Evaluation of perfusion CT and dual-energy CT for predicting microvascular invasion of hepatocellular carcinoma Read More »

Bayard Q, Cordier P, Péneau C, Imbeaud S, Hirsch TZ, Renault V, Nault JC, Blanc JF, Calderaro J, Desdouets C, Zucman-Rossi J, Letouzé E.Cancer Res. 2022 Apr 8:OF1-OF12. doi: 10.1158/0008-5472.CAN-21-3665. Abstract Oncogene activation leads to replication stress and promotes genomic instability. Here we combine optical mapping and whole-genome sequencing (WGS) to explore in depth the nature …

Structure, Dynamics, and Impact of Replication Stress-Induced Structural Variants in Hepatocellular Carcinoma Read More »

Sapena V, Enea M, Torres F, Celsa C, Rios J, Rizzo GEM, Nahon P, Mariño Z, Tateishi R, Minami T, Sangiovanni A, Forns X, Toyoda H, Brillanti S, Conti F, Degasperi E, Yu ML, Tsai PC, Jean K, El Kassas M, Shousha HI, Omar A, Zavaglia C, Nagata H, Nakagawa M, Asahina Y, Singal AG, Murphy …

Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: an individual patient data meta-analysis Read More »

Singal AG, Zhang E, Narasimman M, Rich NE, Waljee AK, Hoshida Y, Yang JD, Reig M, Cabibbo G, Nahon P, Parikh ND, Marrero JA. J Hepatol. 2022 Feb 6:S0168-8278(22)00068-X. doi: 10.1016/j.jhep.2022.01.023. Abstract Background: There is controversy regarding the overall value of hepatocellular carcinoma (HCC) surveillance in patients with cirrhosis given a lack of randomized controlled data. To …

HCC Surveillance Improves Early Detection, Curative Treatment Receipt, and Survival in Patients with Cirrhosis: A Systematic Review and Meta-Analysis Read More »

Eric Trépo, Stefano Caruso, Jie Yang, Sandrine Imbeaud, Gabrielle Couchy, Quentin Bayard, Eric Letouzé, Nathalie Ganne-Carrié, Christophe Moreno, Abderrahim Oussalah, Cyrille Féray, Jean Frédéric Blanc, Bruno Clément, Patrick Hillon, Jérôme Boursier, Valérie Paradis, Julien Calderaro, Viviane Gnemmi, Jean-Charles Nault, Jean-Louis Guéant, Jacques Devière, Isabelle Archambeaud, Carole Vitellius, Bruno Turlin, Jean-Pierre Bronowicki, Thierry Gustot, Angela Sutton, GENTHEP Consortium; Marianne Ziol, Pierre Nahon, Jessica Zucman-Rossi Lancet Oncology, Décembre 2021 Background: Hepatocellular carcinoma is a frequent consequence of alcohol-related liver disease, with variable incidence among heavy drinkers. We did …

Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study Read More »