Nestin as a diagnostic and prognostic marker for combined hepatocellular-cholangiocarcinoma

Calderaro J, Di Tommaso L, Maillé P, Beaufrère A, Nguyen CT, Heij L, Gnemmi V, Graham RP, Charlotte F, Chartier S, Wendum D, Vij M, Allende D, Diaz A, Fuster C, Rivière B, Herrero A, Augustin J, Evert K, Calvisi DF, Leow WQ, Wai Leung HH, Bednarsch J, Boleslawski E, Rela M, Wing-Hung Chan A, …

Nestin as a diagnostic and prognostic marker for combined hepatocellular-cholangiocarcinoma Lire la suite »

New concepts in the treatment of hepatocellular carcinoma

Sidali S, Trépo E, Sutter O, Nault JC. Abstract Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death and occurs mainly in the context of chronic liver disease at cirrhosis stage. The Barcelona Clinic Liver Cancer classification, first established in 1999, is the most commonly used staging system for HCC in Western countries …

New concepts in the treatment of hepatocellular carcinoma Lire la suite »

Systemic Treatments with Tyrosine Kinase Inhibitor and Platinum-Based Chemotherapy in Patients with Unresectable or Metastatic Hepatocholangiocarcinoma

Gigante E, Hobeika C, Le Bail B, Paradis V, Tougeron D, Lequoy M, Bouattour M, Blanc JF, Ganne-Carrié N, Tran H, Hollande C, Allaire M, Amaddeo G, Regnault H, Vigneron P, Ronot M, Elkrief L, Verset G, Trepo E, Zaanan A, Ziol M, Ningarhari M, Calderaro J, Edeline J, Nault JC Abstract Backgrounds and aims: Even if …

Systemic Treatments with Tyrosine Kinase Inhibitor and Platinum-Based Chemotherapy in Patients with Unresectable or Metastatic Hepatocholangiocarcinoma Lire la suite »

Management of alcohol-related liver disease: the French Association for the Study of the Liver and the French Alcohol Society clinical guidelines

Louvet A, Trabut JB, Moreno C, Moirand R, Aubin HJ, Ntandja Wandji LC, Nourredine M, Ningarhari M, Ganne-Carrié N, Pageaux GP, Bailly F, Boursier J, Daeppen JB, Luquiens A, Nguyen-Khac E, Anty R, Orban T, Donnadieu-Rigole H, Mallat A, Bureau C, Pariente EA, Paupard T, Benyamina A, Perney P, Mathurin P, Rolland B; for the Groupe collaboratif …

Management of alcohol-related liver disease: the French Association for the Study of the Liver and the French Alcohol Society clinical guidelines Lire la suite »

Comparison of screening strategies with two new tests to score and diagnose varices needing treatment

Calès P, Ravaioli F, Berger A, Farcau O, Festi D, Stefanescu H, Vitellius C, Nahon P, Bureau C, Ganne-Carriè N, Berzigotti A, de Ledinghen V, Petta S.Clin Res Hepatol Gastroenterol. 2022 Apr 22:101925. doi: 10.1016/j.clinre.2022.101925. Abstract Background and aims: We aimed to improve non-invasive screening of varices needing treatment (VNT) and compare different screening strategies. Methods: 2,290 patients …

Comparison of screening strategies with two new tests to score and diagnose varices needing treatment Lire la suite »

Patient Selection for Downstaging of Hepatocellular Carcinoma Prior to Liver Transplantation-Adjusting the Odds?

Seehofer D, Petrowsky H, Schneeberger S, Vibert E, Ricke J, Sapisochin G, Nault JC, Berg T.Transpl Int. 2022 Apr 21;35:10333. doi: 10.3389/ti.2022.10333 Abstract Background and Aims: Morphometric features such as the Milan criteria serve as standard criteria for liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). Since it has been recognized that these criteria are too …

Patient Selection for Downstaging of Hepatocellular Carcinoma Prior to Liver Transplantation-Adjusting the Odds? Lire la suite »

Performance of non-invasive biomarkers compared with invasive methods for risk prediction of posthepatectomy liver failure in hepatocellular carcinoma

Hobeika C, Guyard C, Sartoris R, Maino C, Rautou PE, Dokmak S, Bouattour M, Durand F, Weiss E, Vilgrain V, Beaufrère A, Sepulveda A, Farges O, Paradis V, Luciani A, Lim C, Sommacale D, Scatton O, Laurent A, Nault JC, Soubrane O, Ronot M, Cauchy F.Br J Surg. 2022 Apr 19;109(5):455-463. doi: 10.1093/bjs/znac017. Abstract Background: Posthepatectomy liver …

Performance of non-invasive biomarkers compared with invasive methods for risk prediction of posthepatectomy liver failure in hepatocellular carcinoma Lire la suite »

Prediction of hepatocellular carcinoma in Hepatitis C patients with advanced fibrosis after sustained virologic response

Azzi J, Dorival C, Cagnot C, Fontaine H, Lusivika-Nzinga C, Leroy V, De Ledinghen V, Tran A, Zoulim F, Alric L, Gournay J, Bronowicki JP, Decaens T, Riachi G, Mikhail N, Soliman R, Shiha G, Pol S, Carrat F, Ganne-Carrié N; ANRS-AFEF Hepather Study group. Abstract Background & aims: Prediction of hepatocellular carcinoma (HCC) occurrence in patients …

Prediction of hepatocellular carcinoma in Hepatitis C patients with advanced fibrosis after sustained virologic response Lire la suite »

Evaluation of perfusion CT and dual-energy CT for predicting microvascular invasion of hepatocellular carcinoma

Lewin M, Laurent-Bellue A, Desterke C, Radu A, Feghali JA, Farah J, Agostini H, Nault JC, Vibert E, Guettier C. Abstract Purpose: Evaluation of perfusion CT and dual-energy CT (DECT) quantitative parameters for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC) prior to surgery. Methods: This prospective single-center study included fifty-six patients (44 men; median age 67; range …

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Structure, Dynamics, and Impact of Replication Stress-Induced Structural Variants in Hepatocellular Carcinoma

Bayard Q, Cordier P, Péneau C, Imbeaud S, Hirsch TZ, Renault V, Nault JC, Blanc JF, Calderaro J, Desdouets C, Zucman-Rossi J, Letouzé E.Cancer Res. 2022 Apr 8:OF1-OF12. doi: 10.1158/0008-5472.CAN-21-3665. Abstract Oncogene activation leads to replication stress and promotes genomic instability. Here we combine optical mapping and whole-genome sequencing (WGS) to explore in depth the nature …

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